© 2023 NIVB
Infectious diseases are characterised by complex and dynamic interactions between pathogen virulence factors and host-cell recognition and response systems. Many relationships between pathogens and their hosts have arisen through long-term co-evolution.
As a result, pathogens have developed elegant and diverse mechanisms to evade host immune responses, whereas host cells use their systems to detect and eliminate pathogens.
Our understanding of the complexity of pathogen-host interactions is limited. For this reason, developing new preventive or therapeutic approaches is essential. Research into pathogen-host cell interactions is evolving in response to the emergence of new infectious organisms (SARS-CoV-2 or drug-resistant bacteria). In addition, oncogenic viruses account for 10% of diagnosed cancers.
Despite the importance of the scale of the adverse health and economic impacts of infectious diseases, many unanswered questions remain about the precise mechanisms by which viruses and bacteria multiply in infected organisms and cause disease symptoms.