2022

LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials

D. D. Do Pham, V. Mojr, M. Helusová, G. Mikušová, R. Pohl, E. Dávidová, H. Šanderová, D. Vítovská, K. Bogdanová, R. Večeřová, M. Htoutou Sedláková, R. Fišer, P. Sudzinová, J. Pospíšil, O. Benada, T. Křížek, A. Galandáková, M. Kolář, L. Krásný, and D. Rejman. J Med Chem. 2022 Jul 28;65(14):10045-10078.

doi: 10.1021/acs.jmedchem.2c00684
PMID: 35839126
PMCID: PMC9580004

Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction.

K. Radilová, V. Zima, M. Kráľ, A. Machara, P. Majer, J. Hodek, J. Weber, J. Brynda, T. Strmeň, J. Konvalinka, M. Kožíšek. Antiviral Res. 2022 Dec;208:105449.

doi: 10.1016/j.antiviral.2022.105449
PMID: 36265804

Synthesis and Anticancer and Antiviral Activities of C-2′-Branched Arabinonucleosides

M. Bege, A. Kiss, I. Bereczki, J. Hodek, L. Polyák, G. Szemán-Nagy, L. Naesens, J. Weber, A. Borbás. Int J Mol Sci. 2022 Oct 19;23(20):12566.

doi: 10.3390/ijms232012566
PMID: 36293420
PMCID: PMC9603951

Viral proteases as therapeutic targets

T. Majerová, J. Konvalinka. Mol Aspects Med. 2022 Nov 29;88:101159.

doi: 10.1016/j.mam.2022.101159
PMID: 36459838
PMCID: PMC9706241

Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules

D. Hrebík, M. Gondová, L. Valentová, T. Füzik, A. Přidal, J. Nováček J, P. Plevka. Acta Crystallogr D Struct Biol. 2022 Nov 1;78(Pt 11):1337-1346.

doi: 10.1107/S2059798322009299
PMID: 36322417
PMCID: PMC9629489

Tail proteins of phage SU10 reorganize into the nozzle for genome delivery.

M. Šiborová, T. Füzik, M. Procházková, J. Nováček, M. Benešík, A.S. Nilsson, P. Plevka. Nat Commun. 2022;13(1):5622.

doi: 10.1038/s41467-022-33305-w
PMID: 36153309
PMCID: PMC9509320

Cryo-electron microscopy and image classification reveal the existence and structure of the coxsackievirus A6 virion

C. R. Büttner, R. Spurný, T. Füzik, P. Plevka. Commun Biol. 2022;5(1):898.

doi: 10.1038/s42003-022-03863-2
PMID: 36056184
PMCID: PMC9438360

Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly

D. Grybchuk, M. Procházková, T. Füzik, A. Konovalovas, S. Serva, V. Yurchenko, P. Plevka. Commun Biol. 2022;5(1):847.

doi: 10.1038/s42003-022-03793-z
PMID: 35986212
PMCID: PMC9391438

Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds

T. Füzik, J. Moravcová, S. Kalynych, P. Plevka. J Virol. 2022:e0060422.

doi: 10.1128/jvi.00604-22
PMID: 35939401
PMCID: PMC9472761

Global Transcriptomic Analysis of Bacteriophage-Host Interactions between a Kayvirus Therapeutic Phage and Staphylococcus aureus

A. Finstrlová, I. Mašlaňová, B. G. Blasdel Reuter, J. Doška, F. Götz, R. Pantůček. Microbiol Spectr. 2022 Jun 29;10(3):e0012322.

doi: 10.1128/spectrum.00123-22
PMID: 35435752
PMCID: PMC9241854

Capillary electrophoretic methods for classification of methicillin-resistant Staphylococcus aureus (MRSA) clones

M. Horká, F. Růžička, A. Siváková, P. Karásek, J. Šalplachta, R. Pantůček, M. Roth. Anal Chim Acta. 2022 Sep 22;1227:340305.

doi: 10.1016/j.aca.2022.340305
PMID: 36089316

Magainin 2 and PGLa in Bacterial Membrane Mimics IV: Membrane Curvature and Partitioning.

E.F. Semeraro, P. Pajtinka, L. Marx, I. Kabelka, R. Leber, K. Lohner, R. Vácha, G. Pabst. Biophysical Journal 2022, 121, 1-13,

doi: 10.1016/j.bpj.2022.10.018
PMID: 36258677
PMCID: PMC9748257

Role of population and test characteristics in antigen-based SARS-CoV-2 diagnosis, Czechia, August to November 2021

T. Kliegr, J. Jarkovský, H. Jiřincová, J. Kuchař, T. Karel, R. Tachezy. Euro Surveill. 2022 Aug;27(33):2200070.

doi: 10.2807/1560-7917.ES.2022.27.33.2200070
PMID: 35983773
PMCID: PMC9389858

PD1+CD8+ Cells are an Independent Prognostic Marker in Patients with Head and Neck Cancer

B. Pokrývková, M. Grega, J. Klozar, O. Vencálek, J. Nunvář, R. Tachezy. Biomedicines. 2022 Nov 3;10(11):2794.

doi: 10.3390/biomedicines10112794
PMID: 36359314
PMCID: PMC9687997

The evaluation of an automated mariPOC SARS-CoV-2 antigen test compared to RT-qPCR SARS-CoV-2 assay and comparison of its sensitivity in Delta- and Omicron-variant samples.

M. Krutova, M. Brajerova, Z. Kepka, A. Briksi, P. Hubacek, P. Drevinek. Influenza Other Respir Viruses. 2022 Nov;16(6):1033-1039

doi: 10.1111/irv.13048
PMID: 36065770
PMCID: PMC9530541

Type 1 diabetes incidence increased during the COVID-19 pandemic years 2020–2021 in Czechia: Results from a large population-based pediatric register.

O. Cinek, M. Slavenko, R. Pomahačová, P. Venháčová, L. Petruželková, J. Škvor, D. Neumann, J. Vosáhlo, P. Konečná, K. Kocourková, J. Strnadel, Š. Průhová, Z. Šumník, the ČENDA Register. Pediatr Diabetes. 2022 Nov;23(7):956-960.

doi: 10.1111/pedi.13405
PMID: 35982508
PMCID: PMC9538386

Clostridioides difficile infection: are the three currently used antibiotic treatment options equal from pharmacological and microbiological points of view?

M. Krutova, M. Wilcox, E. Kuijper. Int J Infect Dis. 2022 Nov; 124:118-123.

doi: 10.1016/j.ijid.2022.09.013
PMID: 36155825

Gut microbiome diversity of porcine peritonitis model of sepsis.

M. Chalupova, J. Horak, L. Kramna, L. Nalos, M. Stengl, K. Chudejova, L. Kraftova, O. Cinek, P. Klein, M. Matejovic, J. Hrabak. Sci Rep. 2022 Oct 19;12(1):17430.

doi: 10.1038/s41598-022-21079-6
PMID: 36261543
PMCID: PMC9581925

New concepts in antimicrobial resistance in cystic fibrosis respiratory infections.

P. Drevinek, R. Canton, H. K. Johansen, L. Hoffman, T. Coenye, P. R. Burgel, J. C. Davies. J Cyst Fibros. 2022 Oct 18:S1569-1993(22)01387-X.

doi: 10.1016/j.jcf.2022.10.005
PMID: 36270946

Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases.

V. Studentova, V. Sudova, I. Bitar, V. Paskova, J. Moravec, P. Pompach, M. Volny, P. Novak, J. Hrabak. Sci Rep. 2022 Dec 23;12(1):22235.

doi: 10.1038/s41598-022-26735-5
PMID: 36564543
PMCID: PMC9789108

Evaluation of Non-Invasive Gargle Lavage Sampling for the Detection of SARS-CoV-2 Using rRT-PCR or Antigen Assay.

O. Bouska, H. Jaworek, V. Koudelakova, K. Kubanova, P. Dzubak, R. Slavkovsky, B. Siska, P. Pavlis, J. Vrbkova and M. Hajduch. Viruses. 2022 Dec 19;14(12):2829

doi: 10.3390/v14122829
PMID: 36560833
PMCID: PMC9786102

The Present and Future of Virology in the Czech Republic—A New Phoenix Made of Ashes?

T. Ruml. Viruses. 2022 Jun 14;14(6):1303

doi: 10.3390/v14061303
PMID: 35746773
PMCID: PMC9231214

Tick-borne encephalitis virus capsid protein induces translational shutoff as revealed by its structural-biological analysis.

M. Selinger, R. Novotný, J. Sýs, J. A. Roby, H. Tykalová, G. S. Ranjani, M. Vancová, K. Jaklová, F. Kaufman, M. E. Bloom, Z. Zdráhal, L. Grubhoffer, J. K. Forwood, R. Hrabal, M. Rumlová, J. Štěrba. J Biol Chem. 2022 Nov;298(11):102585

doi: 10.1016/j.jbc.2022.102585
PMID: 36223838
PMCID: PMC9664413

Dynamic evolution of avian RNA virus sensors: Repeated loss of RIG-I and RIPLET.

V. Krchlíková, T. Hron, M. Těšický, T. Li, L. Ungrová, J. Hejnar, M. Vinkler, D. Elleder. Viruses 2023, 15, 3.

doi: 10.3390/v15010003
PMID: 36680044
PMCID: PMC9861763

CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology.

D. Knizkova, M. Pribikova, H. Draberova, T. Semberova, T. Trivic, A. Synackova, A. Ujevic, J. Stefanovic, A. Drobek, M. Huranova, V. Niederlova , O. Tsyklauri, A. Neuwirth, J. Tureckova, O. Stepanek, P. Draber. Nat Immunol 2022 Nov;23(11):1644-1652.

doi: 10.1038/s41590-022-01325-9
PMID: 36271145
PMCID: PMC9663306

Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections.

D. Paprckova, V. Niederlova, A. Moudra, A. Drobek, M. Pribikova, S. Janusova, K. Schober, A. Neuwirth, J. Michalik, M. Huranova, V. Horkova , M. Cesnekova, M. Simova, J. Prochazka, J. Balounova, D. H. Busch, R. Sedlacek, M. Schwarzer, O. Stepanek. Front Immunol. 2022 Oct 6;13:1009198.

doi: 10.3389/fimmu.2022.1009198
PMID: 36275704
PMCID: PMC9582129

The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglyco- side sensitivity through interaction with the inner membrane.

J. Felix, L. Bumba, C. Liesche, A. Fraudeau, F. Rébeillé, J. Y. El Khoury, K. Huard, B. Gallet, Ch. Moriscot, J. P. Kleman, Y. Duhoo, M. Jessop, E. Kandiah, F. Barras, J. Jouhet & I. Gutsche. Nat Commun. 2022 Sep 20;13(1):5502.

doi: 10.1038/s41467-022-32992-9
PMID: 36127320
PMCID: PMC9489729

Avirulent Phenotype promotes Bordetella pertussis Adaptation to the Intramacrophage Environment.

M. R. Farman, D. Petráčková, D. Kumar, J. Držmíšek, A. Saha, I. Čurnová, J. Čapek, V. Hejnarová, F. Amman, I. Hofacker and B. Večerek. Emerg Microbes Infect 2022 Nov 10;1-96.

doi: 10.1080/22221751.2022.2146536
PMID: 36357372
PMCID: PMC9858536

Filamentous hemagglutinin of Bordetella pertussis does not interact with the β2 integrin CD11b/CD18.

M. Golshani, W. Ur Rahman, A. Osickova, J. Holubova, Jinery Lora, N. Balashova, P. Sebo, R. Osicka. Int J Mol Sci. 2022 Oct 20;23(20):12598.

doi: 10.3390/ijms232012598
PMID: 36293453
PMCID: PMC9604300

TldD/TldE peptidases and N-deacetylases: A structurally unique yet ubiquitous protein family in the microbial metabolism.

S. Vobruba, S. Kadlcik, J. Janata, Z. Kamenik. Microbiol Res. 2022 Dec;265:127186.

doi: 10.1016/j.micres.2022.127186
PMID: 36155963

Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism.

V. Hönig, J. Kamiš, A. Maršíková, T. Matějková, P. Stopka, A. Mácová, D. Růžek, J Kvičerová. Microbiol Spectr. 2022 Oct 26;10(5):e0130622

doi: 10.1128/spectrum.01306-22
PMID: 36169417
PMCID: PMC9604079

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