PhD or Postdoc position available: Vácha lab – CEITEC
Published November 2, 2023
Project: Regulation of protein liquid droplets during transcription
Cells employ protein liquid droplets to form dynamic clusters, which function as nanoreactors or storages with the increased local concentration of specific protein components. These membrane-less organelles self-assemble based on weak protein-protein interactions of intrinsically disordered domains. However, the role of specific sequences remains elusive and the mixing between different protein droplets unexplored. This project is focused on the droplets involved in genome transcription, where posttranslational modifications control the droplet composition and regulate the transcription. Expected findings are not only important for the general knowledge but could also be useful in the design of new treatments because translocation malfunction is involved in numerous diseases including cancer. The research is strongly coupled to collaborations with excellent experimental teams and will be more closely discussed during the interview. The employed tools will contain multi-scale simulations using a wide range of advanced sampling techniques and development of protein parametrization.
Eligibility: Outstanding candidates with experience in computer simulations and with an MSc/PhD degree in the fields of biophysics, soft matter physics, physical chemistry, computational chemistry, statistical mechanics, or related fields. Experience with molecular dynamics simulations (with GROMACS, CHARMM, NAMD, AMBER, LAMMPS, etc.) or other simulation techniques (Monte Carlo, DPD, etc.) at the atomistic or coarse-grained level would be an advantage.
Computing Resources: Successful candidates will have access to local computing clusters with 2500 cores and 100 GPUs. Access to Metacentrum NGI – National Grid Infrastructure for computing (with ~20,000 cores) will be also available. Additional resources include the possibility of applying for IT4Inovations, where the group is active.
Competitive salary: depending on the position – supported by grant projects including ERC consolidator grant.
Application procedure: Applications must include a CV, with list of publications and study results, short personal statement (description of research interests, past, and plans), and the name of a person willing to provide a letter of recommendation. Applications with all this material (preferably in a single pdf) should be sent to Robert Vacha (firstname.lastname@example.org).